FISH

Fluorescence in situ hybridization (FISH) is a molecular cytogenetic method, and works as an adjunct to karyotype analysis for the detection of cytogenetic abnormalities. FISH can help provide clarification of G-banded abnormalities or identify cryptic abnormalities not visible by karyotype analysis. The main advantages of FISH include: high sensitivity and specificity, rapid turnaround time, capacity to analyze large numbers of cells, and ability to obtain adequate data from samples with a low mitotic index or terminally differentiated cells. Also, dividing cells are not required for FISH analysis using both fresh tissue and paraffin embedded tissue.

In general, two hundred interphase cells are analyzed per probe by two independent ASCP certified Cytogenetic Technologist (100 cells/reader).

FISH is most useful when the analysis is targeted toward specific translocation, rearrangement and gain or loss that are known to be associated with a particular disease. We offer the following Disease-focused FISH panels with the best-in-industry turnaround time (1-2 days )