DIAGNOSTIC SERVICES
Next Generation Sequencing
While NGS has the power to sequence the entire human genome, our disease-focused panels are designed to target genes and fusion transcripts with clear diagnostic, therapeutic, or prognostic value. Our approach reduces unclear variants that occur in broader and non-specific NGS panels leading to more actionable results.
Turnaround time: 3-5 days
Hematology Panels
Myeloid Panel
Our comprehensive myeloid panel is a targeted NGS assay that interrogates, not only all relevant DNA mutations and insertions-deletions (up to 176 bp in length), but also fusion transcripts associated with myeloid disorders at a very high sensitivity level (3% LOD) in a single NGS run.
Diseases covered:
AML, MDS, MPN, CMML, JMML, CLL
| AML Panel (19 Genes) | ||||
| ASXL1 | DNMT3A | IDH2 | NPM1 | TET2 |
| BRAF | FLT3 | JAK2 | NRAS | TP53 |
| CBL | GATA2 | KIT | PTPN11 | WT1 |
| CEBPA | IDH1 | KRAS | RUNX1 | |
| MDS Panel (19 Genes) | ||||
| ASXL1 | EZH2 | KRAS | SETBP1 | TP53 |
| DNMT3A | IDH1 | NRAS | SF3B1 | U2AF1 |
| ETV6 | IDH2 | RPS14 | SRSF2 | ZRSR2 |
| EVI1 | KDM6A/UTX | RUNX1 | TET2 | |
| MPN Panel (16 Genes) | |||
| ASXL1 | EZH2 | IDH2 | SETBP1 |
| CALR | JAK2 | MPL | SRSF2 |
| CSF3R | JAK3 | NRAS | TET2 |
| DNMT3A | IDH1 | SH2B3 | TP53 |
| CMML Panel (18 Genes) | ||||
| ASXL1 | EZH2 | NOTCH1 | SF3B1 | TP53 |
| CBL | JAK3 | NRAS | SRSF2 | U2AF1 |
| CSF3R | KRAS | RUNX1 | TET2 | ZRSR2 |
| DNMT3A | MPL | SETBP1 | ||
|
CLL Panel (17 Genes) |
||||
|
ATM |
CD79B |
MYD88 |
PTEN |
XPO |
|
BTK |
DDX3X |
NOTCH1 (hotspots) |
PTPN6 |
|
|
BIRC3 |
FBXW7 |
PIK3CA (hotspots) |
SF3B1 |
|
|
CARD11 |
MAPK1 |
PIK3CD (hotspots) |
TP53 |
|
Solid Tumor Gene Panel
| MPN Panel (16 Genes) | |
| AKT1 | IDH2 |
| ALK | JAKI |
| AR | JAK1 |
| BRAF | JAK2 |
| CDK4 | JAK3 |
| CTNNB1 | KIT |
| DDR2 | KRAS |
| EGFR | MAP2K1 |
| ERBB2 | MAP2K2 |
| ERBB3 | MET |
| ERBB4 | MTOR |
| ESR1 | NRAS |
| FGFR2 | PDGFRA |
| FGFR3 | PIK3CA |
| GNA11 | RAF1 |
| GIVAQ | RET |
| HRAS | ROS1 |
| IDH1 | SMO |
| Copy Number Genes (19 Genes) | |
| AKT1 | FGFR2 |
| ALK | FGFR3 |
| AR | FGFR4 |
| BRAF | KIT |
| CCNDI | KRAS |
| CDK4 | MET |
| CDK6 | MYC |
| EGFR | MYCN |
| ERBB2 | PDGFRA |
| FGFR1 | PIK3CA |
| Gene Fusions (23 Genes) | |
| ABL1 | FGFR2 |
| AKT3 | FGFR3 |
| ALK | MET |
| AXL | NTRK1 |
| BRAF | NTRK2 |
| EGER | NTRK3 |
| ERBB2 | PDGFRA |
| ERG | PPARG |
| ETV1 | RAF1 |
| ETV4 | RET |
| ETV5 | ROS1 |
| FGFR1 | |
Tumor Specific Panels
| Colorectal Panel (14 GENES) | |||||
| AKT1 | BRAF | EGFR | ERBB2 | ERBB4 | FGFR2 |
| FGFR3 | HRAS | KRAS | MET | MAP2K1 | NRAS |
| NTRK1 | PIK3CA | ||||
| Gynecologic Panel (12 GENES) | |||||
| AKT1 | BRAF | AR | EGFR | ERBB2 | ESR1 |
| FGFR1 | FGFR2 | KRAS | MYC | NTRK1 | PIK3CA |
| Melanoma Panel (12 GENES) | ||||||
| BRAF | CDK4 | CTNNB1 | GNA11 | GNAQ | KIT | MAP2K1 |
| NRAS | NTRK1 | PDGFRA | PIK3CA | SMO | ||
| Melanoma Panel (12 GENES) | ||||||||
| ATK1 | ALK | BRAF | DDR2 | EGFR | ERBB2 | FGFR1 | KRAS | MAP2K1 |
| MET | NRAS | NTRK1 | PIK3CA | |||||
| Urologic Panel (7 GENES) | |||||
| AR | ERG | ETV1 | ETV4 | MYC | NTRK1 |
| PALB2 | |||||