DIAGNOSTIC SERVICES

Next Generation Sequencing

While NGS has the power to sequence the entire human genome, our disease-focused panels are designed to target genes and fusion transcripts with clear diagnostic, therapeutic, or prognostic value. Our approach reduces unclear variants that occur in broader and non-specific NGS panels leading to more actionable results.
Next Generation Sequencing
ZTurnaround time: 3-5 days

Hematology Panels

Myeloid Panel
Our comprehensive myeloid panel is a targeted NGS assay that interrogates, not only all relevant DNA mutations and insertions-deletions (up to 176 bp in length), but also fusion transcripts associated with myeloid disorders at a very high sensitivity level (3% LOD) in a single NGS run.
Diseases covered:
AML, MDS, MPN, CMML, JMML, CLL

AML Panel (19 Genes)
ASXL1 DNMT3A IDH2 NPM1 TET2
BRAF FLT3 JAK2 NRAS TP53
CBL GATA2 KIT PTPN11 WT1
CEBPA IDH1 KRAS RUNX1
MDS Panel (19 Genes)
ASXL1 EZH2 KRAS SETBP1 TP53
DNMT3A IDH1 NRAS SF3B1 U2AF1
ETV6 IDH2 RPS14 SRSF2 ZRSR2
EVI1 KDM6A/UTX RUNX1 TET2
MPN Panel (16 Genes)
ASXL1 EZH2 IDH2 SETBP1
CALR JAK2 MPL SRSF2
CSF3R JAK3 NRAS TET2
DNMT3A IDH1 SH2B3 TP53

 

CMML Panel (18 Genes)
ASXL1 EZH2 NOTCH1 SF3B1 TP53
CBL JAK3 NRAS SRSF2 U2AF1
CSF3R KRAS RUNX1 TET2 ZRSR2
DNMT3A MPL SETBP1  

CLL Panel (17 Genes)

ATM
(exons 2-63)

CD79B
(exons 4-5)

MYD88
(exons 3-5)

PTEN
(hotspots)

XPO
(exons 12, 13, 15)

BTK
(exons 14-16)

DDX3X
(exons 7-9, 11, 14)

NOTCH1 (hotspots)

PTPN6
(hotspots)

BIRC3
(exons 6-8)

FBXW7
(exons 6-9)

PIK3CA (hotspots)

SF3B1
(hotspots)

CARD11
(exons 2-8)

MAPK1
(exon 7)

PIK3CD (hotspots)

TP53
(exons 2-11)