DIAGNOSTIC SERVICES

Next Generation Sequencing

While NGS has the power to sequence the entire human genome, our disease-focused panels are designed to target genes and fusion transcripts with clear diagnostic, therapeutic, or prognostic value. Our approach reduces unclear variants that occur in broader and non-specific NGS panels leading to more actionable results.
Next Generation Sequencing
ZTurnaround time: 3-5 days

Hematology Panels

Myeloid Panel
Our comprehensive myeloid panel is a targeted NGS assay that interrogates, not only all relevant DNA mutations and insertions-deletions (up to 176 bp in length), but also fusion transcripts associated with myeloid disorders at a very high sensitivity level (3% LOD) in a single NGS run.
Diseases covered:
AML, MDS, MPN, CMML, JMML, CLL

AML Panel (19 Genes)
ASXL1 DNMT3A IDH2 NPM1 TET2
BRAF FLT3 JAK2 NRAS TP53
CBL GATA2 KIT PTPN11 WT1
CEBPA IDH1 KRAS RUNX1
MDS Panel (19 Genes)
ASXL1 EZH2 KRAS SETBP1 TP53
DNMT3A IDH1 NRAS SF3B1 U2AF1
ETV6 IDH2 RPS14 SRSF2 ZRSR2
EVI1 KDM6A/UTX RUNX1 TET2
MPN Panel (16 Genes)
ASXL1 EZH2 IDH2 SETBP1
CALR JAK2 MPL SRSF2
CSF3R JAK3 NRAS TET2
DNMT3A IDH1 SH2B3 TP53

 

CMML Panel (18 Genes)
ASXL1 EZH2 NOTCH1 SF3B1 TP53
CBL JAK3 NRAS SRSF2 U2AF1
CSF3R KRAS RUNX1 TET2 ZRSR2
DNMT3A MPL SETBP1  

CLL Panel (17 Genes)

ATM
(exons 2-63)

CD79B
(exons 4-5)

MYD88
(exons 3-5)

PTEN
(hotspots)

XPO
(exons 12, 13, 15)

BTK
(exons 14-16)

DDX3X
(exons 7-9, 11, 14)

NOTCH1 (hotspots)

PTPN6
(hotspots)

BIRC3
(exons 6-8)

FBXW7
(exons 6-9)

PIK3CA (hotspots)

SF3B1
(hotspots)

CARD11
(exons 2-8)

MAPK1
(exon 7)

PIK3CD (hotspots)

TP53
(exons 2-11)

Solid Tumor Gene Panel

MPN Panel (16 Genes)
AKT1 IDH2
ALK JAKI
AR JAK1
BRAF JAK2
CDK4 JAK3
CTNNB1 KIT
DDR2 KRAS
EGFR MAP2K1
ERBB2 MAP2K2
ERBB3 MET
ERBB4 MTOR
ESR1 NRAS
FGFR2 PDGFRA
FGFR3 PIK3CA
GNA11 RAF1
GIVAQ RET
HRAS ROS1
IDH1 SMO

 

Copy Number Genes (19 Genes)
AKT1 FGFR2
ALK FGFR3
AR FGFR4
BRAF KIT
CCNDI KRAS
CDK4 MET
CDK6 MYC
EGFR MYCN
ERBB2 PDGFRA
FGFR1 PIK3CA

 

Gene Fusions (23 Genes)
ABL1 FGFR2
AKT3 FGFR3
ALK MET
AXL NTRK1
BRAF NTRK2
EGER NTRK3
ERBB2 PDGFRA
ERG PPARG
ETV1 RAF1
ETV4 RET
ETV5 ROS1
FGFR1

 

 

Tumor Specific Panels

Colorectal Panel (14 GENES)
AKT1 BRAF EGFR ERBB2 ERBB4 FGFR2
FGFR3 HRAS KRAS MET MAP2K1 NRAS
NTRK1 PIK3CA

 

Gynecologic Panel (12 GENES)
AKT1 BRAF AR EGFR ERBB2 ESR1
FGFR1 FGFR2 KRAS MYC NTRK1 PIK3CA

 

Melanoma Panel (12 GENES)
BRAF CDK4 CTNNB1 GNA11 GNAQ KIT MAP2K1
NRAS NTRK1 PDGFRA PIK3CA SMO

 

Melanoma Panel (12 GENES)
ATK1 ALK BRAF DDR2 EGFR ERBB2 FGFR1 KRAS MAP2K1
MET NRAS NTRK1 PIK3CA

 

Urologic Panel (7 GENES)
AR ERG ETV1 ETV4 MYC NTRK1
PALB2