DIAGNOSTIC SERVICES

Next Generation Sequencing

While NGS has the power to sequence the entire human genome, our disease-focused panels are designed to target genes and fusion transcripts with clear diagnostic, therapeutic, or prognostic value. Our approach reduces unclear variants that occur in broader and non-specific NGS panels leading to more actionable results.
Next Generation Sequencing

ZTurnaround time: 3-5 days

Hematology Panels

Comprehensive Myeloid Panel
Our comprehensive myeloid NGS panel streamlines the analysis of hematologic malignancies by consolidating multiple complex tests into a single, targeted assay. This panel delivers broad and clinically relevant coverage of the key genetic alterations driving myeloid disorders.

With a total of 69 target genes (comprising 40 key DNA target genes and 29 critical driver genes within a broad fusion panel) the assay enables sensitive detection of DNA mutations, insertions/deletions, and fusion transcripts at a limit of detection as low as 3%. This powerful approach reduces turnaround time, increases efficiency, and provides deeper insights into the molecular drivers of disease.

Diseases covered include:

  • Acute Myeloid Leukemia (AML)
  • Myelodysplastic Syndromes (MDS)
  • Myeloproliferative Neoplasms (MPN)
  • Chronic Myeloid Leukemia (CML)
  • Chronic Myelomonocytic Leukemia (CMML)
  • Juvenile Myelomonocytic Leukemia (JMML)
  • Mast Cell Leukemia
Hotspot genes (23) Full genes (17) Fusion driver genes (29) Expression genes (5) Expression control genes (5)
ABL1 KRAS
BRAF MPL
CBL MYD88
CSF3R NPM1
DNMT3A NRAS
FLT3 PTPN11
GATA2 SETBP1
HRAS SF3B1
IDH1 SRSF2
IDH2 U2AF1
JAK2 WT1
KIT
ASXL1 PRPF8
BCOR RB1
CALR RUNX1
CEBPA SH2B3
ETV6 STAG2
EZH2 TET2
IKZF1 TP53
NF1 ZRSR2
PHF6
ABL1 HMGA2 PDGFRA
ALK JAK2 PDGFRB
BCL2 KMT2A (MLL) RARA
BRAF MECOM RBM15
CCND1 MET RUNX1
CREBBP MLLT10 TCF3
EGFR MLLT3 TFE3
ETV6 MYBL1
FGFR1 MYH11
FGFR2 NTRK3
FUS NUP214
BAALC
MECOM
MYC
SMC1A
WT1
EIF2B1
FBXW2
PSMB2
PUM1
TRIM27

Comprehensive Lymphoid Panel

Our lymphoid NGS panel delivers comprehensive profiling across 66 lymphoma-associated genes. This design enables sensitive detection of clinically significant mutations, insertions/deletions, and splice-site variants with a variant allele frequency (VAF) threshold of 3%.

The panel addresses the complexity and heterogeneity of lymphoid neoplasms in a single, streamlined assay, eliminating the need for multiple sequential tests. It provides broad molecular insights that support diagnosis, prognostic stratification, and therapeutic decision-making, while also aligning with NCCN and WHO guidelines.

Diseases covered include:

  • Chronic Lymphocytic Leukemia (CLL)
  • Marginal Zone Lymphoma
  • Lymphoplasmacytic Lymphoma (LPL)
  • Follicular Lymphoma (FL)
  • Mantle Cell Lymphoma (MCL)
  • Hairy Cell Leukemia
  • Diffuse Large B-Cell Lymphoma (DLBCL)
  • Other Lymphoid Neoplasms
Full Genes
ATM
CREBBP
KMT2D
NOTCH1
TP53
Hotspot
ARID1A DDX3X JAK2 NRAS SETD2 XPO1
B2M DNMT3A JAK3 PAX5 SF3B1
BCL2 EP300 KLF2 PHF6 SGK1
BIRC3 EZH2 KMT2C PIK3CA SOCS1
BRAF FBXW7 KRAS PIM1 SPEN
BTK FOXO1 MAP2K1 PLCG2 STAT3
CARD11 GNA13 MEF2B PRDM1 STAT5B
CD79B ID3 MTOR PTEN STAT6
CDKN1B IDH1 MYC PTPN11 TCF3
CDKN2A IDH2 MYD88 PTPRD TET2
CIITA IRF4 NF1 RB1 TNFAIP3
CXCR4 JAK1 NOTCH2 RHOA NFRSF14

Solid Tumor Panels

Solid Tumor Gene Panel
Our Oncomine Focus Assay (OFA) is a targeted next-generation sequencing (NGS) panel designed to detect the most clinically relevant genomic alterations across a wide range of solid tumors. This assay consolidates multiple testing methods into a single, streamlined workflow, providing fast and comprehensive insights to support precision oncology.
The OFA interrogates 52 key cancer driver genes, covering the most common classes of alterations, including hotspot mutations, copy number variations (CNVs), and gene fusions. This broad profiling allows simultaneous detection of actionable biomarkers with high sensitivity using limited FFPE tissue samples.

Hotspot Genes (35 Genes)
AKI1 IDH2
ALK JAKI
AR JAK1
BRAF JAK2
CDK4 JAK3
CTNNB1 KIT
DDR2 KRAS
EGFR MAP2K1
ERBB2 MAP2K2
ERBB3 MET
ERBB4 MTOR
ESR1 NRAS
FGFR2 PDGFRA
FGFR3 PIK3CA
GNA11 RAF1
GIVAQ RET
HRAS ROS1
IDH1 SMO

 

Copy Number Genes (19 Genes)
AKT1 FGFR2
ALK FGFR3
AR FGFR4
BRAF KIT
CCNDI KRAS
CDK4 MET
CDK6 MYC
EGFR MYCN
ERBB2 PDGFRA
FGFR1 PIK3CA

 

Gene Fusions (23 Genes)
ABL1 FGFR2
AKT3 FGFR3
ALK MET
AXL NTRK1
BRAF NTRK2
EGER NTRK3
ERBB2 PDGFRA
ERG PPARG
ETV1 RAF1
ETV4 RET
ETV5 ROS1
FGFR1

 

 

Tumor Specific Panels

Colorectal Panel (14 GENES)
AKT1 BRAF EGFR ERBB2 ERBB4 FGFR2
FGFR3 HRAS KRAS MET MAP2K1 NRAS
NTRK1 PIK3CA

 

Gynecologic Panel (12 GENES)
AKT1 BRAF AR EGFR ERBB2 ESR1
FGFR1 FGFR2 KRAS MYC NTRK1 PIK3CA

 

Melanoma Panel (12 GENES)
BRAF CDK4 CTNNB1 GNA11 GNAQ KIT MAP2K1
NRAS NTRK1 PDGFRA PIK3CA SMO

 

Lung Panel (13 GENES)
ATK1 ALK BRAF DDR2 EGFR ERBB2 FGFR1 KRAS MAP2K1
MET NRAS NTRK1 PIK3CA

 

Urologic Panel (7 GENES)
AR ERG ETV1 ETV4 MYC NTRK1
PALB2